What does this research mean for the field?

Gomisin B promotes ferroptosis in neuroblastoma by inhibiting the ESR1/USP7/SREBF1 axis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research investigates how gomisin B affects ferroptosis in neuroblastoma by targeting specific molecular pathways.

March 12, 2026Open Access

Gomisin B promotes RSL3-induced ferroptosis in neuroblastoma by inhibiting the ESR1/USP7/SREBF1 axis

Key Points

This research investigates how gomisin B affects ferroptosis in neuroblastoma by targeting specific molecular pathways.
Studied the impact of gomisin B on neuroblastoma cells
Analyzed transcriptional activation of USP7
Examined the deubiquitination process of SREBF1
Gomisin B downregulated ESR1 levels
Inhibition of USP7 was observed
SREBF1 deubiquitination was suppressed, leading to increased ferroptosis

Abstract

Gomisin B inhibited the transcriptional activation of USP7 by downregulating ESR1, thereby suppressing the deubiquitination of SREBF1. This enhanced NB ferroptosis to alleviate NB progression.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Authors

Mengyao Dong

Ting Gao

Yongtao Xu

Journals

Cell Biology and Toxicology

Actions

Institutions

Taian City Central Hospital

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Gomisin B promotes RSL3-induced ferroptosis in neuroblastoma by inhibiting the ESR1/USP7/SREBF1 axis

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study