The on-site CT-derived fractional flow reserve shows high rule-out capability for significant disease in patients with suspected stenosis at CCTA.
Does on-site CT-derived fractional flow reserve accurately predict invasive fractional flow reserve and absolute myocardial blood flow in patients with suspected chronic coronary syndrome?
38 patients (89 vessels) with suspected chronic coronary syndrome and ≥50% diameter stenosis on CCTA, mean age 64, 76% male. Scanned on GE Revolution Apex CT.
On-site computed tomography-derived fractional flow reserve (CT-FFR) using prototype research software (XFFR version 1.4, GE Research)
Invasive fractional flow reserve (FFR) and absolute myocardial blood flow (MBF) by [15O]H2O PET
Agreement of CT-FFR and invasive FFRsurrogate
A novel on-site CT-FFR algorithm demonstrated high sensitivity and negative predictive value for ruling out functionally significant coronary artery disease compared to invasive FFR, though specificity was moderate.
A novel on-site CT-FFR algorithm demonstrates fast and very high rule-out capability and incremental rule-in potential beyond diameter stenosis for functionally significant disease determined by invasive FFR in patients with suspected stenosis at CCTA. Both measures of FFR correlated weakly with myocardial blood flow and flow reserve by 15OH2O PET.
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Jacob Hartmann Søby
Laust Dupont Rasmussen
Jonathan Nørtoft Dahl
Journal of cardiovascular computed tomography
University Hospital of Zurich
Aarhus University Hospital
Regionshospitalet Viborg
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Søby et al. (Sun,) reported a other. The on-site CT-derived fractional flow reserve shows high rule-out capability for significant disease in patients with suspected stenosis at CCTA.
www.synapsesocial.com/papers/69b3aaa802a1e69014ccb7d8 — DOI: https://doi.org/10.1016/j.jcct.2026.02.007