Going-with-the-flow: nickel-catalysed Suzuki–Miyaura cross-couplings in continuous flow and translation into APIs savolitinib and baxdrostat

Puntos clave

• This research investigates the effectiveness of nickel-catalyzed Suzuki–Miyaura reactions in continuous flow for API synthesis.
• Optimized Ni-catalyzed Suzuki–Miyaura reactions using continuous flow.
• Applied methodology to synthesize complex APIs.
• Explored sustainability in chemical processes.
• Achieved efficient synthesis of savolitinib and baxdrostat using continuous flow.
• Demonstrated the versatility of a sustainable methodology for cross-couplings.

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