What question did this study set out to answer?

To explore the effect of mavacamten on LVOT obstruction and its implications for TMVR.

March 15, 2026Open Access

Mavacamten Reduces LVOT Obstruction Risk, Enabling Transseptal Mitral Valve-in-Valve for Degenerated Bioprosthesis

To explore the effect of mavacamten on LVOT obstruction and its implications for TMVR.
Short-term intervention with mavacamten
Assessment of LVOT obstruction risk
Examination of CT screening feasibility
Potential application of transseptal mitral valve-in-valve method.
Mavacamten reduces LVOT obstruction risk
Facilitates a feasible TMVR pathway in selected patients
Converts CT screening into a viable option for treatment.

In selected patients with prohibitive neo-LVOT, short-term mavacamten may convert CT screening to a feasible TMVR pathway.

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Hoss et al. (Sun,) studied this question.

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Alexander Hoss

F. Voß

Amin Polzin

JACC Case Reports

Heinrich Heine University Düsseldorf

Düsseldorf University Hospital

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