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Hematopoietic Stem Cell Transplantation in Rheumatic Diseases | Synapse

March 15, 2026

Hematopoietic Stem Cell Transplantation in Rheumatic Diseases

Key Points

To evaluate the effectiveness of hematopoietic stem cell transplantation in patients with rheumatic diseases.
Assess patients with refractory SSc, SLE, RA, DADA2, ANCA-associated vasculitis, TA, and JIA for HSCT
Review and optimize conditioning protocols
Investigate patient selection criteria
Evaluate long-term outcomes post-transplant
HSCT achieves long-term, drug-free remission in select patients
Optimizing protocols could improve safety and effectiveness
Need for further research on long-term outcomes

Abstract

HSCT offers a transformative approach for select patients with refractory SSc, SLE, RA, DADA2, ANCA-associated vasculitis, TA, and JIA, achieving long-term, drug-free remission in some. Future research should optimize conditioning protocols, refine patient selection, and assess long-term outcomes to maximize HSCT benefits and minimize risks.

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Authors

N

Nandana Suresh

D

D. R. Spoorthy Raj

H

Harshwardhan Patil

Journals

International Journal of Rheumatic Diseases

Actions

Institutions

JSS Academy of Higher Education and Research

Apollo Hospitals

JSS Medical College and Hospital

References and Citations

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Cite this study

Suresh et al. (Sun,) studied this question.

www.synapsesocial.com/papers/69b6069b83145bc643d1ca57 — DOI: https://doi.org/10.1111/1756-185x.70604