Selection of Temperature and Time Modes of Vacuum Freeze Drying of Peptide-Based Pharmaceuticals

To increase the number of peptide-based drugs produced, an important task is to reduce time costs for the realization of technological stages. One of the longest, energy- and resource-consuming stages of production is vacuum freeze drying. Therefore, in this work we conducted experimental studies on the selection of temperature and time modes of vacuum freeze drying of peptide-based pharmaceuticals. As a result of the experiments, a mode was selected that provides the residual moisture content in the samples not more than 2.5%, no boiling in the first period of drying and minimal shrinkage. Also in the work mathematical modeling of vacuum freeze drying process was carried out using the software package Comsol Multiphysics (calculation of sublimation front motion in a single H5 vial).