What question did this study set out to answer?

To report a case of adalimumab-induced sarcoidosis-like reaction during treatment for Crohn’s disease.

March 18, 2026Open Access

Adalimumab-induced sarcoid-like reaction during treatment for Crohn’s disease：a case report

Key Points

To report a case of adalimumab-induced sarcoidosis-like reaction during treatment for Crohn’s disease.
Patient treated with adalimumab for Crohn’s disease
Observed new symptoms of lymphadenopathy and pulmonary ground-glass opacities
Confirmed diagnosis through bronchoscopy and biopsy
Switched to ustekinumab after drug suspension
Monitored outcomes over one year
Patient experienced improvement after stopping adalimumab
Crohn's disease entered remission on ustekinumab
No recurrence of sarcoidosis-like reaction observed
Highlights the potential for adverse reactions with immune-modulating drugs

Abstract

症例は32歳男性．クローン病に対しTNFα阻害薬adalimumabで治療中，縦隔・肺門リンパ節腫大と両肺すりガラス陰影が新たに発生した．経気管支肺生検で肉芽腫性炎症を認め，休薬3 ヵ月後に改善を確認し，adalimumabによる薬剤性サルコイド様反応（drug-induced sarcoidosis-like reaction： DISR）と診断した．しかし，同時に原病が悪化し治療選択に難渋した．代替薬としてIL-12／23阻害薬ustekinumabを開始し，1年以上経過したが，原病は寛解しDISRは再燃していない．TNFα阻害薬によるDISRの報告は多いが，IL-12／23阻害薬やインテグリン製剤でも少数例が報告されている．生物学的製剤の急速な普及に伴い，稀な有害事象であるDISRの増加が予測される．臨床医は，既存の報告にかかわらず免疫に関わる薬剤によるDISRを発症する可能性に注意する必要がある．

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Authors

Yoko Kida

Fumiko Yshiyama

Sayaka Fujimoto

Journals

The Japanese Journal of Sarcoidosis and Other Granulomatous Disorders

Actions

Institutions

Kobe City Nishi-Kobe Medical Center

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Adalimumab-induced sarcoid-like reaction during treatment for Crohn’s disease：a case report

Key Points

Abstract

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Discussion

Authors

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References and Citations

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