Discovery of dihydrospirocyclopropane-1,7′-pyrrolo[3,4- d pyrimidine] derivatives as novel ATR inhibitors

Key Points

• The research aims to identify new ATR inhibitors through innovative compound design.
• Utilized a scaffold hopping strategy to design new compounds.
• Synthesized dihydrospiro[cyclopropane-1,7′-pyrrolo[3,4-d]pyrimidine] derivatives.
• Evaluated the biological activity of synthesized compounds.
• Compound 10h demonstrated favorable inhibitory activity against ATR.
• Novel derivatives showed potential for further development as therapeutic agents.

Abstract