What question did this study set out to answer?

Examine the impact of microlesions on cognitive decline and assess the role of DBS in cognitive network recovery.

March 18, 2026Open Access

Dynamic Reconfiguration of Cognitive Networks and Recovery From Microlesion Effects in Parkinson's Disease: Insights From a Longitudinal fNIRS Study

Key Points

Examine the impact of microlesions on cognitive decline and assess the role of DBS in cognitive network recovery.
Longitudinal study using functional near-infrared spectroscopy (fNIRS)
Assessment of cognitive networks in patients with Parkinson's disease
Evaluation of the effects of deep brain stimulation (DBS) on network reorganization
Cognitive decline correlated with acute local network disruption due to microlesions
DBS showed positive influence on functional reorganization of cognitive networks
fNIRS effectively monitors neuroplastic changes induced by DBS in Parkinson's patients

Abstract

Our findings indicate that MLE-related cognitive decline may stem from acute local network disruption, while DBS can promote functional reorganization of cognitive networks. fNIRS proves to be a valuable tool for monitoring DBS-induced neuroplasticity in PD.

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Discussion

Authors

Xiang Wei

Yuting Tian

Qiutian Lu

Journals

CNS Neuroscience & Therapeutics

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Institutions

Nanjing Brain Hospital

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Dynamic Reconfiguration of Cognitive Networks and Recovery From Microlesion Effects in Parkinson's Disease: Insights From a Longitudinal fNIRS Study

Key Points

Abstract

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Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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