Drusenoid macular dystrophies in Singaporean Chinese: first report of Doyne honeycomb retinal dystrophy and late-onset retinal degeneration from Southeast Asia

Key Points

• This research aims to document the occurrence of Doyne honeycomb retinal dystrophy and late-onset retinal degeneration in Southeast Asia.
• Identified families with DHRD and L-ORD in Singaporean Chinese population.
• Analyzed genetic background to determine heritage and mutations.
• Evaluated clinical histories and family patterns of vision loss.
• First documented cases of DHRD and L-ORD in Southeast Asia.
• Identified unique genetic variations not linked to European ancestry.
• Emphasized importance of genetic screening for atypical drusen.

Abstract