Research progress on the mechanism of italicHerba Epimedii/italic in anti-osteoporosis

Puntos clave

• The aim is to summarize the mechanisms and efficacy of Herba Epimedii in preventing and treating osteoporosis.
• Reviewed literature from databases including China National Knowledge Infrastructure, Wanfang, and PubMed for research on Herba Epimedii in the last five years.
• Analyzed experimental and clinical studies focusing on the active components and their roles in osteoporosis treatment.
• Herba Epimedii promotes the proliferation and differentiation of osteoblasts through Wnt/beta-catenin and BMP/Runx2/Osx signaling pathways.
• It inhibits RANKL-mediated activation of osteoclasts and reduces bone resorption.
• The herb shows effects on lipid metabolism, inflammatory response, and exerts estrogen-like effects, maintaining bone homeostasis via gut-bone and brain-bone axes.

Resumen