Therapeutic effect and gut microbiota regulation of italicShenling Kongliu Decoction/italic （参苓控瘤方） in postoperative patients with colorectal adenoma

Key Points

• This research investigates the therapeutic effects of Shenling Kongliu Decoction on clinical symptoms and gut microbiota in postoperative colorectal adenoma patients.
• 62 postoperative patients with colorectal adenoma were randomly assigned to treatment and control groups.
• The treatment group received Shenling Kongliu Decoction for three months.
• Colonoscopy evaluations were performed one year post-surgery.
• Clinical symptoms, recurrence rates, inflammatory cytokines, intestinal barrier function, and gut microbiota composition were measured.
• Statistical analysis utilized SPSS 26.0.
• The treatment group showed a significantly lower recurrence rate (12.90%) compared to the control group (35.48%).
• Clinical symptom scores improved in the treatment group, with a 70.97% effective rate vs. 6.45% in the control group.
• Inflammatory markers (IL-6, TNF-α) and intestinal barrier indicators (DAO, D-LA) significantly decreased, with greater reductions in the treatment group.
• Gut microbiota diversity and abundance were significantly higher in the treatment group, supporting gut balance.

Abstract