Study on role and mechanism of italicTongmai Jiangtang Capsule /italic（通脉降糖胶囊） against diabetes-associated cognitive decline

Key Points

• The aim is to explore the effects and mechanisms of Tongmai Jiangtang Capsule in preventing diabetes-associated cognitive decline.
• Utilized db/db mice to establish a diabetes model
• Administered TMJTC as an intervention
• Measured random blood glucose and cognitive abilities
• Identified brain-penetrating compounds using UHPLC-Q-Exactive HFX
• Conducted GO and KEGG pathway analysis for target gene identification
• TMJTC significantly reduced random blood glucose in diabetic mice and improved cognitive decline
• Identified 58 active compounds in TMJTC
• Discovered 2101 gene targets related to the active compounds
• Core targets involved are TP53, AKT1, TNF, SRC, and CTNNB1
• TMJTC likely regulates ROS-related pathways and AGE-RAGE signaling for its protective effects

Abstract