Transactive response DNA-binding protein of 43 kDa (TDP-43) type-A is associated with frontotemporal lobar degeneration (FTLD). In primary age-related tauopathy (PART), TDP-type-α displays similar features to FTLD-TDP type-A. We compared antemortem MRI volumes of amygdala nuclei and hippocampal subfields between 16 PART-TDP-α and 12 FTLD-TDP-A autopsy-confirmed cases. Hippocampal tail and CA1 body volumes were smaller in PART-TDP-α group, which also had smaller lateral and central amygdala nuclei compared to FTLD-TDP-A group, but differences were non-significant after FDR correction. There is no evidence suggesting that TDP-43 type-A in FTLD affects hippocampal and amygdala volume loss differently than TDP-43 type-α in PART.
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Hossam Youssef
Rodolfo G. Gatto
Nikhil B Ghayal
Journal of Alzheimer s Disease
Mayo Clinic in Arizona
WinnMed
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Youssef et al. (Mon,) studied this question.
www.synapsesocial.com/papers/69ba429c4e9516ffd37a30f5 — DOI: https://doi.org/10.1177/13872877261426494