β-Boron or β-Silicon Effect Enables a Regioselective Ni-Catalyzed Hydrocyanation of Internal Alkynes

Key Points

• The aim is to improve regioselectivity in the hydrocyanation of internal alkynes using nickel catalysts.
• Utilized β-boron or β-silicon as modifying agents in nickel-catalyzed reactions.
• Focused on unsymmetric di-alkyl substituted internal alkynes for improved regio-control.
• Conducted comparative analysis of reaction outcomes based on different catalysts.
• Achieved enhanced regioselectivity in hydrocyanation reactions.
• Successfully synthesized a range of alkenyl nitriles with minimal byproducts.
• Demonstrated the effectiveness of β-boron and β-silicon modifications in controlling reaction pathways.

Abstract