What question did this study set out to answer?

The research aims to understand how aldosterone leads to cardiac fibrosis and electrical dysfunction using a 3D cardiac model.

March 18, 2026

Human 3D Cardiac Microtissue Model to Investigate Aldosterone-Induced Fibrosis and Electrical Dysfunction

Key Result

Aldosterone directly induces fibrosis and QT interval prolongation in human 3D cardiac microtissue models, explaining increased cardiovascular risk in primary aldosteronism.

Key Points

The research aims to understand how aldosterone leads to cardiac fibrosis and electrical dysfunction using a 3D cardiac model.
Developed 3D human cardiac microtissue organoids for experimentation.
Exposed organoids to aldosterone to evaluate its direct effects.
Measured changes in fibrosis and QT interval prolongation.
Aldosterone induced significant fibrosis in the cardiac microtissue model.
Prolongation of the QT interval was observed following aldosterone exposure.
Findings suggest increased cardiovascular risk in patients with high aldosterone levels.

Structured PICO

Population

Human 3D Cardiac Microtissue (hMT) organoids

Intervention

Aldosterone

Outcome

Fibrosis and prolongation of the QT intervalsurrogate

Aldosterone directly induces fibrosis and QT prolongation in a 3D human cardiac microtissue model, providing mechanistic insight into the cardiovascular risk of primary aldosteronism and supporting mineralocorticoid receptor antagonist therapy.

Abstract

3D hMT organoids offer a relevant in vitro model to study aldosterone-mediated cardiac effects. Aldosterone directly induces fibrosis and prolongation of the QT interval in this model, which may partially explain the increase of cardiovascular risk in patients with primary aldosteronism and underscores the benefit of mineralocorticoid receptor antagonist therapy.

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Discussion

Authors

Jacopo Burrello

Giorgia Senesi

Claudia Altomare

Journals

Hypertension

Actions

Institutions

University of Turin

Department of Medical Sciences

Kantonsspital Baden

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Human 3D Cardiac Microtissue Model to Investigate Aldosterone-Induced Fibrosis and Electrical Dysfunction

Key Result

Key Points

Structured PICO

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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