Helicobacter pylori infection promotes gastric carcinogenesis by inducing macrophage M2 polarization through the miR ‐146a‐5p/ TRAF6 signaling pathway

Key Points

• To investigate how Helicobacter pylori infection affects macrophage polarization and its role in gastric carcinogenesis.
• Analyzed macrophage polarization in response to Helicobacter pylori infection.
• Examined the miR-146a-5p/TRAF6 signaling pathway.
• Evaluated the effect of polarization on gastric cancer cell function.
• Helicobacter pylori infection shifted macrophages to the M2 phenotype.
• M1 polarization was inhibited, affecting the immune response.
• Enhanced gastric cancer cell function was associated with M2 polarization.

Abstract