What question did this study set out to answer?

To investigate the role of PAK5 in breast cancer metastasis through β-hydroxybutyrate production.

March 18, 2026

PAK5-Mediated Suppression of β-Hydroxybutyrate Production Promotes Breast Cancer Metastasis and Can Be Overcome with Ketogenic Diet

Key Points

To investigate the role of PAK5 in breast cancer metastasis through β-hydroxybutyrate production.
Analyzed the phosphorylation effects of PAK5 on HMGCS2.
Evaluated breast cancer growth and metastasis in relation to β-hydroxybutyrate levels.
Explored the impact of a ketogenic diet on these pathways.
PAK5 phosphorylation of HMGCS2 was found to inhibit β-hydroxybutyrate production.
Inhibition of β-hydroxybutyrate significantly promoted breast cancer metastasis.
A ketogenic diet showed potential to counteract the effects of PAK5 on β-hydroxybutyrate levels.

Abstract

PAK5-mediated phosphorylation of HMGCS2 promotes breast cancer growth and metastasis by inhibiting β-hydroxybutyrate production, revealing the role of PAK5 in ketone metabolism and highlighting a potential therapeutic target for breast cancer metastasis.

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Discussion

Authors

Yao Xing

Yongqiang Tan

Bei Hu

Journals

Cancer Research

Actions

Institutions

China Medical University

First Hospital of China Medical University

National Institute for Communicable Disease Control and Prevention

References and Citations

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Building similarity graph...

Analyzing shared references across papers

PAK5-Mediated Suppression of β-Hydroxybutyrate Production Promotes Breast Cancer Metastasis and Can Be Overcome with Ketogenic Diet

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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