Surgical resection and adjuvant chemoradiation for a rare mediastinal extraskeletal osteosarcoma compressing the right atrium achieved clinical stability at 11 months despite lung metastases.
56-year-old male presenting with chest tightness and dyspnea due to mediastinal extraskeletal osteosarcoma (ESOS) with cardiac involvement
Surgical resection followed by adjuvant radiation therapy and chemotherapy
This case highlights the diagnostic and therapeutic challenges of rare mediastinal extraskeletal osteosarcoma with cardiac involvement, emphasizing the utility of multimodality imaging.
Mediastinal extraskeletal osteosarcoma (ESOS) with cardiac involvement is extremely rare and aggressive. The authors describe a 56-year-old male individual presenting with chest tightness and dyspnea. Imaging revealed a large pericardial mass compressing the right atrium. Surgical resection was performed, and histopathology findings confirmed high-grade ESOS. The patient underwent adjuvant radiation therapy and chemotherapy. At 6 months, pulmonary metastases were detected, prompting treatment adjustment. At 11-month follow-up, the patient remained clinically stable. This case underscores the utility of multimodality imaging and the diagnostic and therapeutic challenges of this rare malignancy. Keywords: Cardiac, Oncology © RSNA, 2026
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Xinran Huang
Qingchao Meng
Bin Lü
Radiology Cardiothoracic Imaging
Chinese Academy of Medical Sciences & Peking Union Medical College
Fu Wai Hospital
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Huang et al. (Thu,) reported a other. Surgical resection and adjuvant chemoradiation for a rare mediastinal extraskeletal osteosarcoma compressing the right atrium achieved clinical stability at 11 months despite lung metastases.
www.synapsesocial.com/papers/69be37726e48c4981c6770d3 — DOI: https://doi.org/10.1148/ryct.250271