Synthesis, Characterization, and Biological Potentials of Chalcones Derivatives

This work aims at synthesizing chalcone derivatives using Acetophenone and benzaldehyde derivatives as the primary components. The chalcone compounds 1, 2, 3, 4, 5 have been produced through Claisen-Schmidt condensation reaction, which involves combining benzaldehyde derivatives (such as 4-bromobenzaldehyde, 4-hydroxybenzaldehyde, 4-(dimethyl amino)benzaldehyde, and o-Nitro benzaldehyde) with acetophenone or its derivatives. This reaction takes place when an aqueous solution of sodium hydroxide and ethanol are combined at room temperature. The generated products were examined employing carbon-13 nuclear magnetic resonance 13C-NMR, proton nuclear magnetic resonance 1H-NMR, ultraviolet (UV), and infrared (IR) spectroscopic techniques. Each compound was tested to determine how effective it was against bacteria. The agar well-diffusion approach was used to assess the antimicrobial activity. Dimethyl sulfoxide (DMSO) was used to solubilize the compounds and derivatives at a concentration of 20 mg/ml, with a concentration of 0.05 mg/ml for each derivative.