Synthesis of mono-benzodimidazol and bis-benzodimidazoles using Fe3O4@SiO2Pr@Vaniline/bisthioglycolic acid nanoparticles as an effective and reusable nanocatalyst

introduction: Benzimidazole derivatives are very important in many different industries. Some can work like medicines that fight germs, fungi, and cancer. They can help reduce fever, allergies, and inflammation. They can also protect against radiation, help with diabetes, lower blood pressure, and fight malaria and HIV. Pimobendan and Omeprazole are type of medicines that helps the man to Cure the disease. The first benzimidazole, 2,6-dimethylbenzimidazole, was made by Huberker in 1872 by reducing 2-nitro-4-methyl acetanilide. Later, Ladenberg made a similar chemical by heating 3,4-diaminotoluene with acetic acid. The other processes were used to synthesize benzimidazole. This process usually needs a strong acid and sometimes high heat or microwave energy. Another lack was severe conditions and low yield of product. For this reason, a lot of attempts was carried out to preparation of benzimidazoles in new conditions. materials and methods: Organic- inorganic hybrid catalyst named Fe3O4@SiO2Pr@vanillin/bis thioglycolic acid was synthesized and analyzed through several methods, such as FT-IR, VSM, TEM, EDX, and FE-SEM. Then, it was used for the synthesis of benzimidazoles by reacting different aldehydes with 1,2-diaminobenzene. All of synthesized organic compounds were characterized by mp, FT-IR, NMR and elemental analysis. results: This is the first report that uses Fe3O4@SiO2pr@Vanillin/bisthioglycolic acid to create benodimidazoles by reacting different aldehydes with 1,2-diaminobenzene. All the organic compounds that were made have been closely examined. The reaction time is short, and this method works well. The reaction was done without any liquids and in a safe and eco-friendly manner. The method described is completely new. discussion: This is the first report that uses Fe3O4@SiO2pr@Vanillin/bisthioglycolic acid to create benodimidazoles by reacting different aldehydes with 1,2-diaminobenzene. All the organic compounds that were made have been closely examined. The reaction time is short, and this method works well. The reaction was done without any liquids and in a safe and eco-friendly manner. The method described is completely new. conclusion: In summary, a new process has been created to make benzodimidazoles using a catalytic method. This approach offers numerous advantages, such as a straightforward process for completing tasks and tidying up without relying on complicated methods. It works under gentle conditions, uses cheap and readily available starting materials, allows the catalyst to be reused, produces a lot of final product, and takes a short time to react. We believe this method could be a helpful new option for the current techniques in this field.