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March 25, 2026

Increase of post–SARS‐CoV‐2 rashes mimicking penicillin allergy in children with Group A beta‐hemolytic Streptococcus infection: An emerging and challenging issue

This research examines the association between Group A beta-hemolytic Streptococcus infections and rashes that resemble penicillin allergies.
Observational analysis of children with GABHS infection
Assessment of skin rashes observed post-SARS-CoV-2 infection
Exclusion of penicillin allergy through negative delayed-type penicillin tests (DPTs)
A significant number of children exhibited rashes after SARS-CoV-2 infection
These rashes were commonly mistaken for penicillin allergies
Negative DPTs confirmed that these rashes were not due to penicillin hypersensitivity

GABHS may be associated with a rash that mimics delayed penicillin allergy, which is excluded by negative DPTs.

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Catamerò et al. (Sun,) studied this question.

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Francesco Catamerò

Silvia Beretta

Giulia Liccioli

Pediatric Allergy and Immunology

University of Milan

Istituti di Ricovero e Cura a Carattere Scientifico

University of Florence

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