Crosstalk between autophagy and ferroptosis in liver diseases (Review)

Ferroptosis is a novel form of regulated cell death triggered by iron‑dependent accumulation in lipid peroxidation. Multiple intracellular catabolic processes and signaling pathways are implicated in ferroptosis regulation. One is autophagy, which delivers cytoplasmic materials to lysosomes for degradation and is critical for the preservation of cellular homeostasis. The discovered role of autophagy in driving ferroptosis have motivated further explorations of the functional interactions and signal pathways between ferroptosis and autophagy, particularly their crosstalk in the pathogenesis or treatment for various liver diseases, such as drug‑induced liver injury, toxin‑induced liver injury, liver fibrosis and hepatocellular carcinoma. The present review presented an in‑depth overview of research on the crosstalk between autophagy and ferroptosis in diverse liver diseases, including the ones aforementioned. The diverse regulatory mechanisms involved in this process are also analyzed to open a new perspective on the interpretation of liver diseases manifestations and provide potential targets for drug discovery and effective intervene.