What question did this study set out to answer?

To evaluate the effectiveness and tolerability of cenobamate in children with drug-resistant epilepsy.

March 30, 2026Open Access

Cenobamate use for drug-resistant epilepsy in children: A real-world single-center study.

Key Points

To evaluate the effectiveness and tolerability of cenobamate in children with drug-resistant epilepsy.
Single-center real-world study
Evaluated seizure reduction and side effects
Assessed treatment retention rates
Included preschool children as young as 3 years old
Cenobamate reduced seizures by over 50% in 60% of children
12% of children became seizure-free
High treatment retention rate of 91% at 6 months
Cenobamate was effective across both focal and non-focal epilepsy types

Abstract

Highlights1. Cenobamate reduced seizures by >50% in 60% of children with drug-resistant epilepsy; 12% became seizure-free.2. Treatment was well tolerated; most side effects were mild, like fatigue or nausea.3. Retention rates were high; 91% at 6 months and 82% at 12 months of treatment.4. Cenobamate was as effective in preschool children from age 3 years and 15 kg body weight, as in older children. 5. Cenobamate was effective in focal as well as non-focal epilepsy types.

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Discussion

Authors

Ronny Wickström

Maria Dahlin

Mattias Åberg

Journals

European Journal of Paediatric Neurology

Actions

Institutions

Karolinska Institutet

Karolinska University Hospital

Västerås Municipality

References and Citations

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Building similarity graph...

Analyzing shared references across papers

Cenobamate use for drug-resistant epilepsy in children: A real-world single-center study.

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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