Cadherin-mediated differentiation of MSC-derived liver organoids: sequencing at day 7

Key Points

• This research aims to explore how cadherin affects the differentiation of mesenchymal stem cell (MSC) aggregates into liver organoids.
• Used cadherin-functionalized PLGA microspheres for differentiation
• Performed RNA sequencing on day 7 of organoid development
• Analyzed gene expression profiles of differentiated organoids
• Identified key genes involved in liver differentiation
• Demonstrated successful formation of liver-like structures
• Showed enhanced organoid development compared to control conditions

Abstract