What question did this study set out to answer?

The study aims to investigate the role of ZDHHC24 and DNA methylation in the risk of developing intracranial aneurysms.

April 10, 2026Open Access

DNA Methylation‐Regulated ZDHHC24 Exacerbates the Risk of Intracranial Aneurysms

Puntos clave

The study aims to investigate the role of ZDHHC24 and DNA methylation in the risk of developing intracranial aneurysms.
Analyzed the expression levels of ZDHHC24 in relation to IA risk.
Examined DNA methylation loci associated with ZDHHC24.
Utilized statistical models to explore relationships between gene expression and IA susceptibility.
ZDHHC24 overexpression is linked to a higher risk of intracranial aneurysms.
Specific DNA methylation loci mediate the expression of ZDHHC24.
These findings highlight the importance of palmitoylation-related processes in IA pathogenesis.

Resumen

ZDHHC24 overexpression is causally linked to increased IA risk, and this relationship is mediated by specific DNA methylation loci. These findings underscore the roles of palmitoylation-related gene expression and DNA methylation in IA pathogenesis, offering novel insights into the molecular mechanisms underlying IA susceptibility.

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Discussion

Cite this study

Yuan et al. (Wed,) studied this question.

www.synapsesocial.com/papers/69d8930e6c1944d70ce0427b — DOI: https://doi.org/10.1002/brb3.71213

Authors

Hao Yuan

Chang Li

Xin Feng

Journals

Brain and Behavior

Actions

Institutions

Zhujiang Hospital

References and Citations

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Building similarity graph...

Analyzing shared references across papers

DNA Methylation‐Regulated ZDHHC24 Exacerbates the Risk of Intracranial Aneurysms

Puntos clave

Resumen

Citation Network

Connected Papers

Discussion

Cite this study

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion