Chiral Resolution of Racemic Ibuprofen Sodium via Diastereomeric Ionic Cocrystallization with Proline

Key Points

• The study aims to investigate a new method for resolving racemic ibuprofen sodium using diastereomeric ionic cocrystallization.
• Utilized proline as a resolution agent
• Applied diastereomeric ionic cocrystallization technique
• Achieved resolution in a single step
• Achieved enantiomeric excess greater than 90%
• Successfully separated RS-ibuprofen sodium into its chiral components

Abstract