Gamma Knife Pituitary Radiosurgery for Refractory Metastatic Bone Pain: A Single-Centre Retrospective Palliative Case Series

In this small retrospective palliative case series, GKPR was associated with rapid short-term pain reduction in selected patients with refractory cancer-related bone pain without immediate procedure-related complications. Given the limited sample size, short follow-up duration inherent to the palliative setting and absence of systematic endocrine evaluation, conclusions regarding long term durability or safety cannot be drawn. Nonetheless, these observations suggest that GKPR may represent a feasible, minimally invasive, palliative option for carefully selected patients, warranting further prospective investigations.