Photoredox-enabled late-stage functionalization of pyrrolidines in batch and flow: rapid access to benzothiazole hybrids as a new class of cholinesterase inhibitors

Key Points

• This research aims to develop a visible-light-driven protocol for functionalizing N-aryl pyrrolidines and piperidines.
• Developed a photoredox protocol using visible light for reactions
• Conducted heteroarylation of N-aryl pyrrolidines and piperidines
• Performed experiments in both batch and flow conditions
• Successfully synthesized benzothiazole derivatives as new cholinesterase inhibitors
• Demonstrated rapid access to functionalized compounds
• Achieved the reaction using the novel photoredox method

Abstract