Ber-EP4 is a highly sensitive immunohistochemical marker for cutaneous BCC, showing predominantly diffuse expression across diverse clinicohistologic contexts. However, reduced expression in ulcerated tumors and the presence of nondiffuse staining patterns highlight potential diagnostic pitfalls, particularly in superficially sampled lesions. These findings underscore the need for cautious interpretation and integrated histomorphological and immunohistochemical assessment to ensure diagnostic accuracy.
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Giang Huong Tran
Ngoc Hong Nguyen
Huong Ngoc-Thien Duong
American Journal of Dermatopathology
Ho Chi Minh City Medicine and Pharmacy University
HCMC Hospital of Dermato Venereology
University Medical Center HCMC
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Tran et al. (Tue,) studied this question.
www.synapsesocial.com/papers/69d893eb6c1944d70ce04e00 — DOI: https://doi.org/10.1097/dad.0000000000003287