What question did this study set out to answer?

To examine whether selective serotonin reuptake inhibitor (SSRI) treatment in adolescence is linked to later risk of nonaffective psychosis.

April 10, 2026Open Access

Selective Serotonin Reuptake Inhibitor Treatment in Adolescence and Subsequent Risk of Nonaffective Psychosis: A Quasi‐Experimental Study

Key Points

To examine whether selective serotonin reuptake inhibitor (SSRI) treatment in adolescence is linked to later risk of nonaffective psychosis.
Quasi-experimental design utilized to assess outcomes
Examination of SSRIs as a treatment for common mental disorders (CMDs)
Analysis of psychosis risk following SSRIs treatment during adolescence
No evidence supporting a causal relationship between SSRIs and later psychosis risk
Findings suggest SSRIs do not prevent later psychosis
No significant differences observed in psychosis rates among treated and untreated individuals

Abstract

This quasi-experimental study found no evidence of a causal relationship between SSRI treatment in adolescence and later psychosis risk. Our findings do not support the hypothesis that SSRI treatment of CMDs in adolescence prevents later psychosis.

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Discussion

Authors

Ioanna Kougianou

Animesh Talukder

Kirstie O′ Hare

Journals

Acta Psychiatrica Scandinavica

Actions

Institutions

University of Edinburgh

UNSW Sydney

University College Dublin

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Selective Serotonin Reuptake Inhibitor Treatment in Adolescence and Subsequent Risk of Nonaffective Psychosis: A Quasi‐Experimental Study

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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