Usnic acid chitosan-coated liposomes synergistic activity with polymyxin B against multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii clinical in vitro

Puntos clave

• The aim is to assess the combined effects of usnic acid chitosan-coated liposomes and polymyxin B on multidrug-resistant infections.
• Evaluated the antimicrobial activity of Lipo-UA-Chi with polymyxin B in laboratory settings
• Conducted tests against multidrug-resistant strains of Pseudomonas aeruginosa and Acinetobacter baumannii
• Assessed biofilm control capabilities of the combined treatment
• Lipo-UA-Chi combined with polymyxin B significantly enhances antimicrobial efficacy
• The combination shows improved biofilm control in tested bacterial strains
• Findings suggest potential as an alternative treatment for resistant infections

Resumen