What question did this study set out to answer?

This study aims to assess the effects of low-dose theophylline on lung function and exacerbation rates in patients with mild to moderate COPD.

April 10, 2026Open Access

Low-dose theophylline in mild to moderate Chronic Obstructive Pulmonary Disease: A randomized clinical trial in China

Key Points

This study aims to assess the effects of low-dose theophylline on lung function and exacerbation rates in patients with mild to moderate COPD.
Conducted as a randomized clinical trial
Included individuals diagnosed with mild to moderate COPD
Administered low-dose theophylline and monitored lung function parameters
Low-dose theophylline was well-tolerated among participants
Did not significantly reduce exacerbation rates
Showed a modest improvement in pre-bronchodilator FEV1, though limited in magnitude

Abstract

In mild to moderate COPD, low-dose theophylline was well-tolerated but did not reduce exacerbation rates. A modest improvement in pre-bronchodilator FEV1 was observed, though its magnitude was limited. Larger trials are needed to further evaluate its potential to improve lung function in this population.

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Discussion

Authors

Yang Zhou

Cuiqiong Dai

Fan Wu

Journals

Pulmonology

Actions

Institutions

Shanghai Jiao Tong University

Central South University

Southern University of Science and Technology

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Low-dose theophylline in mild to moderate Chronic Obstructive Pulmonary Disease: A randomized clinical trial in China

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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