What question did this study set out to answer?

This research aims to understand how dystrophin is localized within muscle cells and the implications for therapy.

April 10, 2026Open Access

Myonuclear Domain‐Associated and Central Nucleation‐Dependent Spatial Restriction of Dystrophin Protein Expression

Key Points

This research aims to understand how dystrophin is localized within muscle cells and the implications for therapy.
Investigated dystrophin expression in myofibers
Analyzed central nucleation impact on dystrophin localization
Evaluated barriers to dystrophin restoration
Identified spatial restrictions in dystrophin expression within myofibers
Revealed significant challenges to therapeutic restoration in centrally nucleated fibers
Demonstrated the importance of myonuclear domain in effective muscle repair

Abstract

These findings reveal new insights into the importance of dystrophin spatial localization and identify a previously unappreciated barrier to effective therapeutic dystrophin restoration, particularly within regenerated or centrally nucleated myofibers.

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Authors

Katarzyna Chwalenia

Vivi‐Yun Feng

Nicole Hemmer

Journals

Journal of Cachexia Sarcopenia and Muscle

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Institutions

University of Oxford

University of Florida

University of Tübingen

References and Citations

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Building similarity graph...

Analyzing shared references across papers

Myonuclear Domain‐Associated and Central Nucleation‐Dependent Spatial Restriction of Dystrophin Protein Expression

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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