Longitudinal Assessment of Biomarkers in ALS : Discriminative Biomarkers for Disease Progression and Survival

Puntos clave

• The research aims to identify biomarkers that can effectively differentiate between ALS disease progression and patient survival.
• Longitudinal assessment of biomarkers in ALS patients
• Evaluated 4-HNE, LBP, and NfL levels
• Correlation analysis with disease burden and survival outcomes
• Increased levels of 4-HNE and LBP correlated with greater disease burden and faster progression.
• Bulbar onset patients had shorter survival linked to higher 4-HNE and LBP levels.
• Combining these biomarkers may improve monitoring for clinical trials.

Resumen