Lysosome-Targeting Protein Degradation: From Mechanistic Insights to Strategic Design

Key Points

• The review aims to summarize the advancements in lysosome-targeting protein degradation (LTPD) and its implications for disease intervention.
• Review of recent literature on lysosome-targeting protein degradation (LTPD) technologies
• Analysis of molecular design principles and mechanisms of LTPD
• Summary of the applications of LTPD in targeting various biomolecules and organelles
• LTPD shows unique advantages in degrading challenging targets like membrane proteins and damaged organelles.
• Chemical design strategies enable precise control over lysosomal pathways, expanding therapeutic options.
• LTPD may provide multidimensional intervention strategies for diseases linked to lysosomal dysfunction.

Abstract