Prediction Score of Cervical Intraepithelial Neoplasia Grade II or Higher (CIN2+) in Patients with Low-Grade Cytology (ASC-US, LSIL) and HPV- Negative or Non-type 16/18 High-Risk HPV-Positive Results

Key Points

• To evaluate a predictive model for identifying patients at risk for CIN2+ among those with low-grade cytology results and specific HPV statuses.
• Analyzed risk factors associated with CIN2+ including reproductive history, sexual partners, smoking, screening status, HPV vaccination history, and HPV type.
• Developed a predictive model to assess sensitivity and negative predictive value.
• Considered patients with low-grade cytology results like ASC-US and LSIL along with HPV testing outcomes.
• The predictive model exhibited a high sensitivity of 97.3%, indicating it effectively identifies most true positives for CIN2+.
• The negative predictive value was 98.6%, suggesting a low rate of false negatives among those predicted not to have CIN2+.

Abstract