In vitro and in vivo assessment of sporopollenin exine capsule preparations (SpECs) from Lycopodium clavatum spores

Puntos clave

• The aim is to evaluate the allergenic potential of sporopollenin exine capsule preparations derived from Lycopodium clavatum spores.
• Conducted in vitro assessments of SpECs for allergenicity.
• Performed in vivo evaluations to confirm findings.
• Analyzed the impact of SpECs on allergenic responses.
• Identified varying levels of allergenicity in the preparations.
• Demonstrated that some SpECs could be used safely in oral drug delivery.
• Highlighted the need for further testing to ensure therapeutic safety.

Resumen