What question did this study set out to answer?

To explore the neuroprotective effects of hydrogen gas therapy in a schizophrenia-like mouse model.

April 10, 2026Open Access

Hydrogen Gas Therapy in Schizophrenia: Potential Neuroprotective Effects From an Animal Study

Key Points

To explore the neuroprotective effects of hydrogen gas therapy in a schizophrenia-like mouse model.
Utilized MK-801-induced mouse model to simulate schizophrenia-like behavior.
Administered hydrogen gas therapy to evaluate its effects on behavior and oxidative stress.
Compared behavioral abnormalities and antioxidant levels pre- and post-treatment.
Hydrogen gas therapy did not significantly improve behavioral abnormalities in the model.
Beneficial antioxidant effects were observed following hydrogen gas treatment.

Abstract

These findings suggest that hydrogen gas therapy does not significantly ameliorate behavioral abnormalities in the MK-801-induced schizophrenia-like mouse model but exerts beneficial antioxidant effects. Future studies should evaluate hydrogen gas as an adjunctive therapy and further assess its efficacy and safety in clinical settings.

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Discussion

Authors

Nobumi Miyake

Toshiaki Haga

Shin‐Ichi Hirano

Journals

Neuropsychopharmacology Reports

Actions

Institutions

St. Marianna University School of Medicine

University of Tokyo Health Sciences

Shonan Kamakura General Hospital

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Hydrogen Gas Therapy in Schizophrenia: Potential Neuroprotective Effects From an Animal Study

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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