Ligand-Free Nickel-Catalyzed Arylation Cascades for Accessing Pyrrolopyridin-2-one, Pyranoindole-2,7-dione, and Indolin-2-one Frameworks with Mechanistic Insights

Key Points

• The research investigates a ligand-free nickel-catalyzed reaction for synthesizing various lactam frameworks.
• Utilized a tandem carbocyclization-arylation reaction
• Employed a ligand-free nickel catalyst
• Assessed substrate tolerance for product diversity
• Conducted mechanistic analysis of the reaction
• Successfully produced indolin-2-one and pyrrolo[3,2-b]pyridin-2-one frameworks
• Demonstrated broad substrate tolerance
• Achieved regioselective access to desired lactam products

Abstract