Two successful deliveries following fertility-sparing treatment for synchronous endometrial and ovarian cancer: a case report and literature review

Fertility-sparing treatment is a viable treatment option for selected patients with endometrial or ovarian cancer. However, its use in synchronous endometrial and ovarian cancer (SEOC) remains rare, and standardized treatment strategies have yet to be established. We report the case of a 26-year-old woman diagnosed with SEOC, characterized as grade 1, stage IA endometrioid carcinoma of both the endometrium and ovary. Genetic analysis ruled out hereditary cancer syndromes, including Lynch syndrome. The patient was treated with medroxyprogesterone acetate for 26 weeks, after which histological evaluation confirmed complete remission. She subsequently achieved two spontaneous pregnancies, both resulting in uncomplicated vaginal deliveries. To our knowledge, this is the fifth reported case of childbirth following fertility-sparing treatment for SEOC and the first involving two successful deliveries.