Enhanced viral inactivation by photodynamic therapy using curcumin and methylene blue: An in vitro study with bacteriophage as a viral model

Key Points

• This research aims to explore how effectively photodynamic therapy using curcumin and methylene blue inactivates viruses, specifically utilizing a bacteriophage model.
• Conducted in vitro experimentation using bacteriophages as viral models.
• Applied antimicrobial photodynamic therapy (aPDT) with curcumin and methylene blue photosensitizers.
• Assessed viral inactivation in the presence of oxygen.
• Demonstrated significant viral inactivation using curcumin and methylene blue under aPDT.
• Noted enhanced effectiveness in the presence of oxygen compared to absence.
• Observed a clear correlation between the concentration of photosensitizers and the degree of viral inactivation.

Abstract