What question did this study set out to answer?

The research aims to evaluate the relationship between FOXO3 polymorphisms and glioblastoma prognosis.

April 10, 2026

Single-Nucleotide Polymorphisms rs2253310 and rs4946936 in the forkhead box O3 Gene and Their Correlation with Prognosis in Glioblastoma

Key Points

The research aims to evaluate the relationship between FOXO3 polymorphisms and glioblastoma prognosis.
Analyzed single-nucleotide polymorphisms in the FOXO3 gene
Assessed overall survival (OS) and progression-free survival (PFS)
Performed statistical correlations between genotypes and survival outcomes
No significant association with glioblastoma susceptibility or overall survival found
Mutant genotypes correlated with improved progression-free survival
Findings suggest potential prognostic relevance of these polymorphisms

Abstract

FOXO3 rs2253310 and rs4946936 polymorphisms are not significantly associated with glioblastoma susceptibility or OS. Nevertheless, the mutant genotypes correlate with improved PFS, highlighting their possible prognostic relevance. Larger, multicentric studies are warranted to validate these findings and explore the underlying biological mechanisms.

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Discussion

Authors

Shamanaz

Shivanjali Raghuvanshi

Atin Singhai

Journals

Annals of African Medicine

Actions

Institutions

King George's Medical University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Single-Nucleotide Polymorphisms rs2253310 and rs4946936 in the forkhead box O3 Gene and Their Correlation with Prognosis in Glioblastoma

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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