Does signal complexity correlate with secondary insults and long-term outcomes in patients with malignant middle cerebral artery infarction post-decompressive craniectomy?
Patients with malignant middle cerebral artery infarction (MMI) post-decompressive craniectomy (DC) undergoing neurointensive care
Monitoring of systemic and cerebral signal complexity (SC), heart rate variability, and baroreflex sensitivity
Burden of secondary insults and long-term outcomesurrogate
Lower signal complexity in patients with malignant middle cerebral artery infarction post-decompressive craniectomy may serve as a prognostic marker for reduced tolerance to secondary insults and worse long-term outcomes.
Lower systemic and cerebral SC correlated with greater burden of secondary insults and worse long-term outcome in MMI post-DC. Low SC may indicate overloaded systemic and cerebral compensatory mechanisms, resulting in reduced tolerance for secondary insults. SC may aid prognostication and fine-tune NIC to identify and prevent autoregulatory insults.
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Modar Alhamdan
Anders Hånell
Timothy Howells
Neurocritical Care
Uppsala University
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Alhamdan et al. (Tue,) studied this question.
www.synapsesocial.com/papers/69d895486c1944d70ce06384 — DOI: https://doi.org/10.1007/s12028-026-02506-2