Interrelationship Between Baseline HbA1c , SGLT ‐2 Inhibitor Use and Risk of Diabetic Ketoacidosis in Adults With Type 2 Diabetes: A Systematic Review and Meta‐Analysis

Key Points

• To explore how baseline HbA1c and the use of SGLT-2 inhibitors relate to the risk of diabetic ketoacidosis in adults with type 2 diabetes.
• Conducted a systematic review of existing literature
• Included studies analyzing the correlation between HbA1c and SGLT-2 inhibitor use
• Performed a meta-analysis to quantify the risk of diabetic ketoacidosis
• Found a significant association between elevated HbA1c levels and increased risk of diabetic ketoacidosis
• Demonstrated that SGLT-2 inhibitors are linked to higher rates of diabetic ketoacidosis
• Highlighted potential implications for monitoring patients on SGLT-2 inhibitors

Abstract