Intrahepatic cholestasis of pregnancy and offspring neurodevelopment: bile acid-mediated mechanisms and long-term neurodevelopmental outcomes

Key Points

• This research aims to explore the potential long-term neurodevelopmental effects of intrahepatic cholestasis of pregnancy in offspring through bile acid-mediated mechanisms.
• Assessment of maternal bile acid levels during pregnancy.
• Evaluation of placental function and dysfunction.
• Longitudinal tracking of child neurodevelopmental outcomes.
• Refinement of exposure assessment methods.
• Evidence suggests maternal bile acids may contribute to neurodevelopmental risks in offspring.
• Identified mechanisms link placental dysfunction with neurodevelopmental outcomes.
• Emphasizes the need for further longitudinal studies to clarify these associations.

Abstract