A systematic review on clinical pharmacokinetics and pharmacodynamics of antiangiogenic tyrosine kinase inhibitors (TKIs) with high TDM scores

Puntos clave

• The review aims to evaluate the clinical pharmacokinetics and pharmacodynamics of antiangiogenic tyrosine kinase inhibitors (TKIs).
• Conducted a systematic literature review
• Analyzed pharmacokinetic and pharmacodynamic properties
• Evaluated therapeutic drug monitoring (TDM) scores
• Identified key pharmacokinetic parameters of various TKIs
• Highlighted implications of TDM scores on drug efficacy
• Discussed the variability in drug response among different populations

Resumen