What question did this study set out to answer?

The aim is to investigate the role of CD8+ regulatory T cells in modulating eosinophilic infiltration in an allergic asthma model.

April 10, 2026

Novel CD8 + Regulatory T Cells Attenuate Eosinophilic Infiltration in a Murine Allergic Asthma Model

Key Points

The aim is to investigate the role of CD8+ regulatory T cells in modulating eosinophilic infiltration in an allergic asthma model.
Utilized a murine model induced by OVA for asthma.
Administered CD8+ T regulatory cells derived from B cells.
Measured levels of Th2 cytokines (IL-4, IL-5, IL-13) and eosinophilic infiltration in BALF.
CD8+ Tregs significantly suppressed Th2 cytokine proliferation.
Eosinophilic infiltration in bronchoalveolar lavage fluid (BALF) was downregulated by CD8+ Tregs.

Abstract

Summary CD8 + Treg‐of‐B cells suppressed Th2 proliferation and the levels of IL‐4, IL‐5, and IL‐13. In an OVA‐induced asthma model, CD8 + Treg‐of‐B cells downregulated eosinophilic infiltration in BALF.

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Discussion

Authors

Jia‐Ning Fan

T.-T. Chen

Bor‐Luen Chiang

Journals

Clinical & Experimental Allergy

Actions

Institutions

National Taiwan University

National Taiwan University Hospital

References and Citations

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Novel CD8 + Regulatory T Cells Attenuate Eosinophilic Infiltration in a Murine Allergic Asthma Model

Key Points

Abstract

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Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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