Multimodal Assessment of Biological Age Following Radiation Therapy Among Patients With Early-Stage NSCLC

Key Points

• This study aims to evaluate the association of biological age with survival outcomes among older patients with early-stage NSCLC after radiation therapy.
• Conducted a cohort study involving older patients with early-stage NSCLC receiving stereotactic body radiation therapy (SBRT).
• Assessed biological age using facial analysis and lung age through spirometry.
• Analyzed the relationship between biological age and survival outcomes.
• Face age was identified as an independent biomarker linked to survival and early mortality.
• Biological and lung age measures helped in individualized risk stratification.
• Noninvasive assessment methods were found to be complementary and beneficial for treatment planning.

Abstract