Myeloid/lymphoid precursor cell neoplasms and mixed phenotype acute leukemias: A Bone Marrow Workshop Report from the 22nd European Association for Hematopathology/Society of Hematopathology Meeting, Dubrovnik, 2024

Key Points

• To address the classification challenges of mixed phenotype acute leukemias and myeloid/lymphoid precursor cell neoplasms.
• Discussion of the classification issues at the Hematopathology Meeting
• Proposal of a genomic classification framework
• Analysis of gene mutations including MR and TP53
• Identified frequent mixed phenotype in AML-MR cases
• Highlighted phenotypic and genetic overlaps in various leukemias
• Proposed a new framework to improve diagnostic accuracy for MPAL and related neoplasms

Abstract